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Oxygen Mass Transfer in Biopharmaceutical Processes: Numerical and Experimental Approaches
Author(s) -
Seidel Stefan,
Maschke Rüdiger W.,
Werner Sören,
Jossen Valentin,
Eibl Dieter
Publication year - 2020
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.202000179
Subject(s) - mass transfer , aeration , oxygen , bioreactor , bubble , mass transfer coefficient , chemistry , biopharmaceutical , chemical oxygen demand , thermodynamics , steady state (chemistry) , mechanics , chromatography , environmental science , environmental engineering , physics , wastewater , organic chemistry , biology , genetics
Oxygen supply in aerobic bioprocesses is of crucial importance. For this reason, this paper presents the oxygen demand of different cells and summarizes experimental and numerical possibilities for the determination of oxygen transfer in bioreactors. The focus lies on the volumetric oxygen mass transfer coefficient ( k L a ) calculation using computational fluid dynamics and state‐of‐the‐art models for surface‐aerated and forced‐aerated bioreactors. In addition, experimental methods for the determination of the k L a value and the gas bubble size distribution are presented.