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Optimized Process and Bioreactor Characterization
Author(s) -
Maischberger Thomas
Publication year - 2019
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201900134
Subject(s) - bioreactor , mixing (physics) , aeration , process engineering , biochemical engineering , characterization (materials science) , mass transfer , process (computing) , computer science , mass transfer coefficient , materials science , chemistry , engineering , chromatography , nanotechnology , physics , waste management , organic chemistry , quantum mechanics , operating system
The mass transfer coefficient ( k L )and the value of the interfacial area ( a ) is used to characterize bioreactor systems for their oxygen transfer capability. The k L a value and the mixing time are amongst the most important performance indicators for bioreactors. Their calculation and modeling is extremely complex in highly aerated systems. This paper describes a new methodology for measuring the k L a value to accurately determine the coefficient. The valuable insights obtained allow for improved bioreactor characterization, thus, making it easier to meet regulatory requirements. Furthermore, examples outlining the benefits in the practical application of the new methodology are presented.