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Scale‐up of Microfiltration Processes
Author(s) -
Haindl Susanne,
Stark Julia,
Dippel Jannik,
Handt Sebastian,
Reiche Annette
Publication year - 2020
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201900025
Subject(s) - microfiltration , filtration (mathematics) , cross flow filtration , fouling , volumetric flow rate , flow (mathematics) , materials science , mechanics , chemistry , membrane , mathematics , biochemistry , physics , statistics
A flow rate and resistance‐based approach for upscaling of microfiltration processes from lab scale to process scale is presented, in correlation with biopharmaceutical processes. Basic element is the modeling of filtration curves using a resistance‐in‐series model based on the Darcy equation. The influences of the filtration setup and the fouling layer are described as additional resistances that change in course of filtration. The necessary parameters, such as setup resistances and filtration areas, are determined by water flow rate measurements. The model is validated by filtration of a particulate test solution. The presented approach can be used for constant flow and constant pressure driven filtration processes.