Premium
Formation of Mefenamic Acid Nanocrystals with Improved Dissolution Characteristics
Author(s) -
Konnerth Christoph,
Braig Veronika,
Ito Atsutoshi,
Schmidt Jochen,
Lee Geoffrey,
Peukert Wolfgang
Publication year - 2017
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201600190
Subject(s) - mefenamic acid , dissolution , particle size , nanocrystal , materials science , chemical engineering , kinetics , particle (ecology) , chromatography , chemistry , nanotechnology , physics , oceanography , quantum mechanics , geology , engineering
An industrially feasible formulation approach combining media milling and spray‐drying was applied to improve dissolution characteristics of the poorly soluble drug mefenamic acid (MA). The approach was studied for two MA polymorphs at different stressing and pH conditions. It was found that final MA product particle sizes are rather determined by the solid‐liquid equilibrium than by mechanical fracture. Obtained drug particles are only composed of the most stable polymorph. Direct compressed tablets containing MA nanocrystals exhibit a significant improvement of in vitro dissolution kinetics as compared to tablets with micronized drug particles.