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Redispersion of Nanoparticle‐Loaded Orodispersible Films: Preservation of Particle Fineness
Author(s) -
Steiner Denise,
Finke Jan Henrik,
Kwade Arno
Publication year - 2017
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201600139
Subject(s) - fineness , nanoparticle , particle (ecology) , materials science , polymer , economies of agglomeration , chemical engineering , particle size , nanotechnology , matrix (chemical analysis) , bioavailability , manufacturing process , dissolution , composite material , engineering , oceanography , geology , bioinformatics , biology
The application of orodispersible films (ODFs) as carrier for drug nanoparticles was discovered a few years ago. Poorly water‐soluble drugs are milled to nanosuspensions to improve their bioavailability. During the manufacturing process they are embedded into a polymer matrix or loaded on the surface of drug‐free ODF templates. The particle size of the particles released from the ODF was measured when redispersed in water. A preservation of the drug particle sizes could be achieved for both investigated ODF types when an adequate amount of matrix material is added to prevent agglomeration during the drying process.