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Simplified, High Drug‐Loaded Formulations Containing Hydrochlorothiazide for Twin‐Screw Granulation
Author(s) -
Meier Robin,
Moll KlausPeter,
Krumme Markus,
Kleinebudde Peter
Publication year - 2017
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201600134
Subject(s) - tableting , granulation , hydrochlorothiazide , ultimate tensile strength , materials science , granule (geology) , quality by design , drug , composite material , biomedical engineering , chromatography , chemistry , chemical engineering , pharmacology , particle size , medicine , engineering , blood pressure , radiology
Simplified, high drug loaded formulations for use in twin‐screw granulation and tableting were introduced, using the plastically deforming drug ibuprofen. This concept was enlarged by application of hydrochlorothiazide, because opposed deformation behavior was expected to result in different product performances. In most instances the results differed. Critical quality attributes like granule size distribution, disintegration time, and tensile strength of tablets could be met. The study confirms the suitability of simplified formulation with differently behaving drugs for pharmaceutical product design in continuous manufacturing.