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Hybrid Alginate‐Based Cryogels for Life Science Applications
Author(s) -
Barros Alexandre,
Quraishi Sakeena,
Martins Marta,
Gurikov Pavel,
Subrahmanyam Raman,
Smirnova Irina,
Duarte Ana Rita C.,
Reis Rui L.
Publication year - 2016
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201600096
Subject(s) - gellan gum , gelatin , materials science , chemical engineering , cytotoxicity , porosity , hybrid material , sodium alginate , tissue engineering , composite material , chemistry , biomedical engineering , nanotechnology , organic chemistry , in vitro , medicine , biochemistry , food science , engineering , metallurgy , sodium
This work presents a novel route toward porous scaffolds for tissue engineering and regenerative medicine (TERM) applications. Hybrid cryogels with gelatin, gellan gum, carboxymethylcellulose, and lignin were prepared by a two‐step process. Textural properties of the cryogels were analyzed by SEM and micro‐computed tomography. The results indicated that rapid freezing retained sample shape and yielded macroporous materials. The mechanical properties of the cryogels were characterized in compression mode. Cytotoxicity studies indicated that the hybrid‐alginate cryogels did not present cytotoxicity and have the potential to be used in TERM.