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Modeling the Kinetics of Protein Conjugation Reactions
Author(s) -
Pfister David,
Ulmer Nicole,
Klaue Antoine,
Ingold Oliver,
Morbidelli Massimo
Publication year - 2016
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201600046
Subject(s) - kinetics , chemistry , chemical kinetics , reagent , chemical reaction , biochemical engineering , computational chemistry , organic chemistry , engineering , quantum mechanics , physics
Over the past decades, the pharmaceutical industry has shown a continuous infatuation for therapeutic proteins. In order to constantly improve their efficacy, chemical reactions involving the conjugation of the therapeutic protein with various chemical reagents have been developed. Little efforts have been put forth to simulate the kinetics of protein conjugation and the literature dealing with kinetic models is rather scarce as compared to the abundant references about conjugation reactions in general. In this work, techniques to measure the kinetics of reaction, model the conjugation between add‐on molecules and proteins, and evaluate the model parameters are discussed.