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Quantitative Online NMR Spectroscopy in a Nutshell
Author(s) -
Zientek Nicolai,
Meyer Klas,
Kern Simon,
Maiwald Michael
Publication year - 2016
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201500120
Subject(s) - nuclear magnetic resonance spectroscopy , transverse relaxation optimized spectroscopy , spectroscopy , process (computing) , deuterium nmr , chemistry , analytical chemistry (journal) , materials science , fluorine 19 nmr , computer science , chromatography , organic chemistry , physics , quantum mechanics , operating system
Online NMR spectroscopy is an excellent tool to study complex reacting multicomponent mixtures and gain process insight and understanding. For online studies under process conditions, flow NMR probes can be used in a wide range of temperature and pressure. This paper compiles the most important aspects towards quantitative process NMR spectroscopy in complex multicomponent mixtures and provides examples. After NMR spectroscopy is introduced as an online method and for technical samples without sample preparation in deuterated solvents, influences of the residence time distribution, pre‐magnetization, and cell design are discussed. NMR acquisition and processing parameters as well as data preparation methods are presented and the most practical data analysis strategies are introduced.