Premium
Accurate Information from Fermentation Processes – Optimal Rate Calculation by Dynamic Window Adaptation
Author(s) -
Zahel Thomas,
Sagmeister Patrick,
Suchocki Szymon,
Herwig Christoph
Publication year - 2016
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201500085
Subject(s) - bioprocess , workflow , computer science , process (computing) , scalability , window (computing) , adaptation (eye) , batch processing , data mining , algorithm , control engineering , biochemical engineering , engineering , physics , optics , database , chemical engineering , programming language , operating system
The calculation of metabolic turnover rates is essential for the scalable design, analysis and control of bioprocesses. A novel rate calculation algorithm is presented that is based on the dynamic adaptation of window sizes in order to deliver robust and precise rates with uniform signal‐to‐noise ratios. Additionally a model‐based generic algorithm for deriving optimal rate calculation workflows was developed. The generic algorithms delivered more precise and accurate rates for online and offline signals, which was demonstrated for both in silico‐ and real batch and fed‐batch fermentation process data. The presented algorithms will strongly support bioprocess development and control as enabling tools for multivariate data analysis, mechanistic modeling and dynamic experimentation.