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Chiral Metal‐Organic Frameworks and Their Application in Asymmetric Catalysis and Stereoselective Separation
Author(s) -
Nickerl Georg,
Henschel Antje,
Grünker Ronny,
Gedrich Kristina,
Kaskel Stefan
Publication year - 2011
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201000188
Subject(s) - catalysis , stereoselectivity , homogeneous , metal organic framework , enantioselective synthesis , selectivity , combinatorial chemistry , metal , heterogeneous catalysis , organic synthesis , homogeneous catalysis , materials science , adsorption , chemistry , nanotechnology , organic chemistry , thermodynamics , physics
The targeted synthesis of a desired stereomer plays a key role in life sciences, especially in the production of drugs. Up to date, this area is dominated by homogeneous chiral catalysts. Metal‐Organic Frameworks (MOFs), a new class of porous materials, consisting of metal‐oxo‐clusters and multifunctional ligands could offer a platform for chiral heterogeneous catalysts combining the efficiency and in particular selectivity observed for homogeneous asymmetric catalysts with the advantages of heterogeneous catalysis. This review summarizes strategies to obtain chiral Metal‐Organic Frameworks and gives an overview about reactions that have been successfully conducted using chiral MOFs as asymmetric catalysts. In addition, some examples highlighting the stereoselective adsorption properties of chiral Metal‐Organic Frameworks are given.