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Estimation of Chromatographic Columns Performances using Computer Tomography and CFD Simulations
Author(s) -
Schmidt Irma,
Lottes Florian,
Minceva Mirjana,
Arlt Wolfgang,
Stenby Erling H.
Publication year - 2011
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.201000171
Subject(s) - computational fluid dynamics , packed bed , mass transfer , mechanics , flow (mathematics) , adsorption , materials science , tomography , dispersion (optics) , chromatography , column (typography) , homogeneous , fluid dynamics , chemistry , mathematics , physics , geometry , thermodynamics , optics , organic chemistry , connection (principal bundle)
The flow inside a chromatographic column depends decisively on the packed bed inside. Non‐destructive X‐ray computed tomography (CT) was applied as a novel measurement technique to visualize the distribution of velocity and axial dispersion coefficients in preparative scale columns. The results show, that spherical particles seem to be more efficient than irregular ones in terms of HETP, which has to be partly a result of the more homogeneous flow profile they induce. The prediction of column performance in dependence of the structure of the packed bed was simulated by CFD (Computational Fluid Dynamics), using a model which besides the hydrodynamics parameters attained by CT also includes adsorption isotherms and mass transfer parameters. The results of the CFD simulation shall help to establish rules for selecting the right adsorption material for a given separation task in advance.