Open AccessHydroxyzine‐induced fixed drug eruption and cross‐reaction with oxatomide
Author(s) -
Terada Mizuki,
Hayashi Shujiro,
Okamoto Maki,
Igawa Ken
Publication year - 2023
Publication title -
journal of cutaneous immunology and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.127
H-Index - 1
ISSN - 2574-4593
DOI - 10.1002/cia2.12275
Subject(s) - piperazine , drug eruption , hydroxyzine , ring (chemistry) , drug reaction , drug , medicine , pharmacology , chemistry , organic chemistry
There are a few reports in the literature implicating them in causing fixed drug eruption, the piperazine derivatives. In this case, although eszopiclone for insomnia medicinehas a piperazine ring, no eruption appeared so far. Oxatomide and hydroxyzine not only shared a piperazine ring but also shared two benzene rings via a methine group (=CH–). It was suspected that this shared structural group became an antigenic determinant and resulted in cross‐reactivity. Such a unique case has not been reported before.