Open AccessRelevance of cutaneous manifestations and antineutrophil cytoplasmic antibody status in eosinophilic granulomatosis with polyangiitis
Author(s) -
Sone Meiko,
Miyabe Chie,
Miyata Ryujin,
Takenaka Yuko,
Ishiguro Naoko
Publication year - 2022
Publication title -
journal of cutaneous immunology and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.127
H-Index - 1
ISSN - 2574-4593
DOI - 10.1002/cia2.12194
Subject(s) - granulomatosis with polyangiitis , medicine , eosinophilic , anti neutrophil cytoplasmic antibody , vasculitis , prednisolone , microscopic polyangiitis , dermatology , immunology , pathology , gastroenterology , disease
Eosinophilic granulomatosis with polyangiitis (EGPA) belongs to the family of antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis syndromes. Although increasing evidence indicates the correlation of clinical and histological features with the presence or absence of ANCAs in EGPA, the variations in cutaneous features according to their ANCA status have not been fully described. Here, we retrospectively reviewed the clinical and histological findings of 9 cases of EGPA, who presented with cutaneous lesions. Our data indicate that ANCA‐positive patients often present with blisters, systemic inflammatory symptoms, and are prone to receive a higher dose of oral prednisolone and additional immunosuppressive therapies.