Open AccessAltered nucleocytoplasmic staining patterns of p62/SQSTM1 in cutaneous squamous cell carcinoma precursors
Author(s) -
Ogawa Tatsuya,
Ishitsuka Yosuke,
Fujimoto Manabu,
Nomura Toshifumi
Publication year - 2021
Publication title -
journal of cutaneous immunology and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.127
H-Index - 1
ISSN - 2574-4593
DOI - 10.1002/cia2.12171
Subject(s) - sequestosome 1 , actinic keratosis , hyperkeratosis , biology , autophagy , cancer research , immunohistochemistry , pathology , cytoplasm , nuclear protein , transcription factor , basal cell , medicine , microbiology and biotechnology , gene , immunology , apoptosis , genetics
We undertook an immunohistochemical study of cutaneous SCC (cSCC) and its precursors actinic keratosis (AK) and Bowen’s disease (BD) and found that nucleocytoplasmic expression patterns of p62 were substantially different between the cSCC precursors. Because p62 serves as a guardian of DNA damage responses, in a similar way as tumor protein 53, we consider that the different staining patterns between AK and BD could reflect distinctive etiopathologies.