Open AccessANCA‐associated neuropathy in systemic sclerosis: A case report and review of literature
Author(s) -
Takenaka Kayo,
Takeichi Takuya,
Nishi Ryoji,
Suzuki Masashi,
Koike Haruki,
Katsuno Masahisa,
OgawaMomohara Mariko,
Muro Yoshinao,
Akiyama Masashi
Publication year - 2021
Publication title -
journal of cutaneous immunology and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.127
H-Index - 1
ISSN - 2574-4593
DOI - 10.1002/cia2.12153
Subject(s) - medicine , autoantibody , interstitial lung disease , systemic disease , peripheral neuropathy , vasculitis , overlap syndrome , complication , pathology , autoimmune disease , disease , dermatology , immunology , antibody , lung , diabetes mellitus , endocrinology
Systemic sclerosis (SSc) is a multi‐system autoimmune disease. Anti‐neutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against enzymes found within primary granules of neutrophils and lysosomes in monocytes. Although up to 12% of SSc patients have ANCA, only a minority of these patients develop an overlap syndrome with ANCA‐associated vasculitis. We summarize previous reports on SSc patients with ANCA‐associated neuropathy. In all the reported cases, the SSc diagnosis preceded the ANCA‐associated neuropathy diagnosis. Seven of the eight patients with limited cutaneous SSc had interstitial lung disease (ILD). Thus, patients with ANCA‐associated neuropathy in lSSc may be prone to complication with ILD.