Open AccessSquamous cell carcinoma–like ungual fibroma as early diagnostic indicators of tuberous sclerosis complex in an elderly patient
Author(s) -
Yokoyama Kae,
Niida Yo,
Ikeda Takaharu,
Takahashi Kazuo,
Kawakami Tamihiro
Publication year - 2020
Publication title -
journal of cutaneous immunology and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.127
H-Index - 1
ISSN - 2574-4593
DOI - 10.1002/cia2.12128
Subject(s) - tuberous sclerosis , tsc1 , basal cell , medicine , dermatology , tsc2 , pathology , biology , genetics , apoptosis , pi3k/akt/mtor pathway
We suggest that these cutaneous manifestations, such as squamous cell carcinoma‐like periungual and subungual fibromas, could serve as markers for making earlier diagnosis in late‐onset patients with TSC1 gene mutations. Therefore, we propose that dermatological examination could be useful for earlier diagnosis in elderly and clinically mild TSC patients.