Open AccessTwo atopic dermatitis patients in whom dupilumab improved aberrant epidermal protease activities
Author(s) -
Nomura Hayato,
Kawakami Yoshio,
Yasutomi Yohei,
Morizane Shin
Publication year - 2019
Publication title -
journal of cutaneous immunology and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.127
H-Index - 1
ISSN - 2574-4593
DOI - 10.1002/cia2.12058
Subject(s) - dupilumab , atopic dermatitis , medicine , eczema area and severity index , regimen , dermatology life quality index , immunology , dermatology , disease
We experienced two cases of AD patients for whom dupilumab treatment was effective and improved epidermal aberrant serine protease activities. Our patients’ cases suggest that this biologic agent not only contributes to a decrease in Th2‐dominant inflammation but also improves the epidermal barrier function of AD patients.