Open AccessTwo cases of ichthyosis and their EPR analyses of stratum corneum
Author(s) -
Minakawa Satoko,
Matsuzaki Yasushi,
Nakagawa Kouichi,
Kaneko Takahide,
Akasaka Eijiro,
Nomura Kazuo,
Sawamura Daisuke
Publication year - 2019
Publication title -
journal of cutaneous immunology and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.127
H-Index - 1
ISSN - 2574-4593
DOI - 10.1002/cia2.12057
Subject(s) - ichthyosis , lamellar ichthyosis , epidermolytic hyperkeratosis , congenital ichthyosis , hyperkeratosis , filaggrin , palmoplantar keratoderma , dyskeratosis , stratum corneum , dermatology , corneocyte , ichthyosis vulgaris , medicine , pathology , atopic dermatitis
Ichthyosis is an inherited skin disorders characterized by generalized scaling and hyperkeratosis. The cause is absence of transglutaminase‐1 (TGM1) in approximately half of all cases of lamellar ichthyosis(OMIM number 242100), supercial epidermolytic ichthyosis (SEI, OMIM 146800) is a rare autosomal dominant skin disorder caused by mutations in the keratin 2 (KRT2) gene. We investigated stratum corneum (SC) radicals of the patients with ichthyosis using the electron paramagnetic resonance (EPR).