Open AccessTransient hypogammaglobulinemia of infancy with no evidence of immunodeficiency other than atopic dermatitis: A case report and review of literature
Author(s) -
Minowa Tomoyuki,
Sumikawa Yasuyuki,
Hida Tokimasa,
Uhara Hisashi
Publication year - 2018
Publication title -
journal of cutaneous immunology and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.127
H-Index - 1
ISSN - 2574-4593
DOI - 10.1002/cia2.12037
Subject(s) - hypogammaglobulinemia , medicine , atopic dermatitis , immunodeficiency , primary immunodeficiency , pediatrics , common variable immunodeficiency , immunology , family history , medical history , atopy , dermatology , immunopathology , antibody , surgery , immune system
We report an infant with transient hypogammaglobulinemia of infancy (THI) who had severe atopic dermatitis (AD), but showed no history of infections. The lack of history of infections poses a risk that the underlying THI may be overlooked because most infants with THI are identified due to the history of infections. Our aim was to carefully delineate the clinical presentations of THI‐associated AD and normal AD through a case report and review of previous literature. Our findings suggest that the history of infections may be an infrequent presentation among patients with THI‐associated AD.