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Stereoselection in designed three‐helix bundle metalloproteins
Author(s) -
Case Martin A.,
Ghadiri M. Reza,
Mutz Mitchell W.,
Mc Lendon George L.
Publication year - 1998
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.7
Subject(s) - chemistry , metalloprotein , chirality (physics) , helix (gastropod) , helix bundle , peptide , stereochemistry , metal , combinatorial chemistry , protein structure , organic chemistry , biochemistry , biology , ecology , chiral symmetry breaking , physics , quantum mechanics , snail , nambu–jona lasinio model , quark
The stereochemical consequences of the metal‐ion assisted self‐assembly of parallel three‐helix peptide bundles are investigated. Chiral induction in the self‐assembly of systems containing extensive protein secondary structure is compared with the racemic synthesis of short metallopeptides. Isolation and characterization of the individual stereoisomers of an exchange‐inert metalloprotein provide structural insights into analogous exchange‐labile systems. Chirality 10:35–40, 1998. © 1998 Wiley‐Liss,Inc.