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Thermal behaviour, phase diagram, and spectroscopic properties of rac ‐indobufen and its enantiomers
Author(s) -
Vigevani Aristide,
Zampieri Massimo
Publication year - 1995
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530070804
Subject(s) - chemistry , differential scanning calorimetry , enantiomer , phase diagram , melting point , phase (matter) , thermal analysis , crystallography , thermal , stereochemistry , thermodynamics , organic chemistry , physics
The binary phase diagram of the enantiomers of indobufen, 1 (Ibustrin), an antithrombotic drug, has been investigated by differential scanning calorimetry (DSC); 1 is a racemic compound (racemate) with melting point lower than that of the enantiomers. Its thermal behaviour (DSC) has been examined and is discussed in comparison with other physical methods (IR spectroscopy and X‐ray powder diffraction). Absolute configuration has been assigned to the enantiomers by 1 H‐NMR correlations. © 1995 Wiley‐Liss, Inc.