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Degradation and racemization of zopiclone enantiomers in plasma and partially aqueous solutions
Author(s) -
Fernandez Christina,
Gimenez François,
Mayrargue Joelle,
Thuillier Alain,
Farinotti Robert
Publication year - 1995
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530070413
Subject(s) - racemization , chemistry , degradation (telecommunications) , enantiomer , hydrolysis , aqueous solution , chromatography , decomposition , carbamate , organic chemistry , telecommunications , computer science
We investigated the degradation and racemization of zopiclone (ZOP) enantiomers in plasma and partially aqueous solutions (ethanol:phosphate buffer). Degradation and racemization increased with increasing pH and temperature. Degradation products were identified by means of mass spectrometry, which revealed hydrolysis of the carbamate function and opening of the pyrrolidone ring. In plasma, neither degradation nor racemization occurred after 6 months of storage at ‐20°C and subsequent extraction. © 1995 Wiley‐Liss, Inc.