Premium
Central composite design for the rapid optimisation of ruggedness and chiral separation of amlodipine in capillary electrophoresis
Author(s) -
Small Tracy S.,
Fell Anthony F.,
Coleman Michael W.,
Berridge John C.
Publication year - 1995
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530070408
Subject(s) - central composite design , chemistry , composite number , amlodipine , resolution (logic) , chromatography , capillary electrophoresis , response surface methodology , electrophoresis , composite material , computer science , materials science , medicine , artificial intelligence , blood pressure , radiology
Systematic optimisation with central composite design offers an efficient route for rapid optimisation of resolution with multiple interacting parameters in chiral CE. This is illustrated by separations of amlodipine with α‐CD as chiral selector in the running buffer, for which the predicted performance of central composite design is assessed. The utility of response surface methodology for locating optimum ruggedness in CE is also described. © 1995 Wiley‐Liss, Inc.