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Solubility phase diagram of praziquantel enantiomeric system
Author(s) -
Lim Beegim,
Tan Reginald B. H.,
Ng Siuchoon,
Ching Chibun
Publication year - 1995
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530070205
Subject(s) - chemistry , enantiomer , solubility , phase diagram , polymorphism (computer science) , crystallization , enantiomeric excess , phase (matter) , solid solubility , organic chemistry , enantioselective synthesis , catalysis , biochemistry , genotype , gene
Abstract The solubility behaviour of praziquantel enantiomeric system at −15°C, 4°C, and 15°C is presented. This system exhibits both a pseudoracemate behaviour and one which leads to the formation of enantiomerically pure crystals. For solutions with lower enantiomeric purity, the pseudoracemate behaviour is more prominent. Solid solutions are formed when the mixtures of the enantiomers are crystallised. The phase diagram shows a complete absence of a eutetic. For mixtures with higher enantiomeric purity, pure crystals of the excess enantiomer are obtained when the solution is crystallised. Temperature dependency of this polymorphism is not significant. With these phase diagrams, a method is suggested to obtain enantiomerically pure isomers of praziquantel from a partially resolved mixture. © 1995 Wiley‐Liss, Inc.