Premium
Stereoselective binding of benzodiazepines and related compounds on calmodulin‐sepharose
Author(s) -
Fitos Ilona,
Visy Jüalia,
Kardos Julianna,
Simonyi Miklóas
Publication year - 1995
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530070204
Subject(s) - chemistry , stereoselectivity , calmodulin , sepharose , chromatography , organic chemistry , catalysis , enzyme
A method has been presented to evaluate the Ca 2+ ‐dependent binding affinity of ligands to calmodulin (CaM) from their chromatographic retentions obtained on a CaM‐Sepharose column. Enantiomers of benzodiazepines and related compounds could be separated. Among chiral calcium antagonists, verapamil showed stereoselectivity of binding. © 1995 Wiley‐Liss, Inc.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom