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K‐Opioid activity of the four stereoisomers of the peripherally selective κ‐agonists, EMD 60 400 and emd 61 753
Author(s) -
Gottschlich Rudolf,
Krug Michael,
Barber Andrew,
Devant Ralf M.
Publication year - 1994
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530060814
Subject(s) - chemistry , opioid , stereochemistry , pharmacology , receptor , biochemistry , medicine
The four stereoisomers of the two peripherally selective κ‐opioid agonists EMD 60 400 and EMD 61 753 were synthesized, tested for stereoisomeric purity, and examined for affinity to the κ opioid receptor. The relationships between the configuration of these molecules and their biological activity are discussed. © 1994 Wiley‐Liss, Inc.