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Direct determination of the enantiomeric purity of (R)‐ and (S)‐2‐hydroxy‐4‐phenylbutyric acid
Author(s) -
Chilmonczyk Zdzisław,
Ksycińska Hanna,
Kruszewska Hanna,
Cybulski Jacek
Publication year - 1994
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530060805
Subject(s) - chemistry , enantiomer , enantiomeric excess , resolution (logic) , chromatography , chiral column chromatography , high performance liquid chromatography , covalent bond , chiral derivatizing agent , stereochemistry , enantioselective synthesis , organic chemistry , catalysis , artificial intelligence , computer science
The determination of enantiomeric purity of (R)‐ and (S)‐2‐hydroxy‐4‐phenylbutyric acid by chiral HPLC is described. Good resolution has been obtained on covalently bonded L‐hydroxyproline saturated with Cu(II) ions. The method makes possible the determination of enantiomeric purity in media containing growing cells. © 1994 Wiley‐Liss, Inc.