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Assignment of absolute configuration to an improved enantioselective naproxen selector
Author(s) -
Pirkle William H.,
Welch Christopher J.,
Wilson Scott R.
Publication year - 1994
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530060803
Subject(s) - chemistry , naproxen , absolute configuration , enantiomer , circular dichroism , enantioselective synthesis , chiral column chromatography , elution , stereochemistry , chiral stationary phase , chromatography , organic chemistry , catalysis , medicine , alternative medicine , pathology
Assignment of absolute configuration to a recently developed chiral selector useful in the separation of the underivatized enantiomers of naproxen and other nonsteroidal anti‐inflammatory drugs (NSAIDs) is described. Circular dichroism, 1 H NMR, and X‐ray diffraction have been used to confirm the original assignment which was based solely upon elution orders from HPLC chiral stationary phases. All of these techniques agree in the assignment of the ( S , S ) absolute configuration to the enantiomer of the chiral selector which associates preferentially with ( S )‐naproxen. © 1994 Wiley‐Liss, Inc.