Separation of the optical isomers of a new 1,4‐dihydropyridine calcium channel blocker (LF 2.0254) by liquid and supercritical fluid chromatography | Zendy

Siret Laurent | Zendy; Macaudiere Pierre | Zendy; BargmannLeyder Nathalie | Zendy; Tambute André | Zendy; Caude Marcel | Zendy; Gougeon Émile | Zendy

Premium

Separation of the optical isomers of a new 1,4‐dihydropyridine calcium channel blocker (LF 2.0254) by liquid and supercritical fluid chromatography

Author(s) -

Siret Laurent,

Macaudiere Pierre,

BargmannLeyder Nathalie,

Tambute André,

Caude Marcel,

Gougeon Émile

Publication year - 1994

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.530060513

Subject(s) - chemistry , supercritical fluid chromatography , chromatography , supercritical fluid , chiral column chromatography , dihydropyridine , high performance liquid chromatography , organic chemistry , calcium

The four optical isomers of a new calcium channel blocker LF 2.0254 (developed by Laboratoires Fournier) are resolved by chromatography using chiral stationary phases. Two methods are proposed: the first one involving two chiral stationary phases [(S)‐ N ‐(2‐naphthyl)alanine, a Pirkle type CSP and Chiralcel OJ, a cellulose derived CSP] in the liquid chromatographic mode, the second one involving a single CSP (Chiralcel OJ) in the supercritical fluid chromatographic mode. © 1994 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research