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Separation of the optical isomers of a new 1,4‐dihydropyridine calcium channel blocker (LF 2.0254) by liquid and supercritical fluid chromatography
Author(s) -
Siret Laurent,
Macaudiere Pierre,
BargmannLeyder Nathalie,
Tambute André,
Caude Marcel,
Gougeon Émile
Publication year - 1994
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530060513
Subject(s) - chemistry , supercritical fluid chromatography , chromatography , supercritical fluid , chiral column chromatography , dihydropyridine , high performance liquid chromatography , organic chemistry , calcium
The four optical isomers of a new calcium channel blocker LF 2.0254 (developed by Laboratoires Fournier) are resolved by chromatography using chiral stationary phases. Two methods are proposed: the first one involving two chiral stationary phases [(S)‐ N ‐(2‐naphthyl)alanine, a Pirkle type CSP and Chiralcel OJ, a cellulose derived CSP] in the liquid chromatographic mode, the second one involving a single CSP (Chiralcel OJ) in the supercritical fluid chromatographic mode. © 1994 Wiley‐Liss, Inc.