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Investigation of the enantioselectivity and enantiomeric elution order of some piperidine‐2,6‐dione drugs on chiralcel OD column
Author(s) -
AboulEnein Hassan Y.,
Serignese Vince
Publication year - 1994
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530060504
Subject(s) - chemistry , enantiomer , piperidine , elution , chromatography , chiral derivatizing agent , chiral column chromatography , organic chemistry , stereochemistry , combinatorial chemistry
The enantioselectivity and enantiomeric separation of five racemic piperidine‐2,6‐dione compounds, on the cellulose tris(3,5‐dimethylphenyl carbamate) chiral stationary phase Chiralcel OD‐CSP were investigated under the same chromatographic conditions. This class of drugs includes glutethimide, aminoglutethimide, cyclohexylaminoglutethimide, pyridoglutethimide, and phenglutarimide. The results revealed that chiral recognition and the binding sites of these drugs on the Chiralcel OD column are similar, regardless of the absolute configuration of the individual enantiomers. A possible chiral recognition mechanism(s) for this class of drugs and the CSP is presented. © 1994 Wiley‐Liss, Inc.