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γ‐Cyclodextrin as chiral mobile phase additive in the HPLC separation of the atropisomers of some N ‐arylthiazoline‐2‐thiones and N ‐arylthiazoline‐2‐ones: Attempts to quantify the effect of selected structural parameters
Author(s) -
Roussel Christian,
Favrou Anita
Publication year - 1993
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530050613
Subject(s) - chemistry , atropisomer , substituent , high performance liquid chromatography , chromatography , chiral column chromatography , enantiomer , chiral stationary phase , phase (matter) , cyclodextrin , organic chemistry
The effect of the position and type of the substituent on the chromatographic separation of N ‐arylthiazoline‐2‐thione and arylthiazoline‐2‐one atropisomers are described in reversed‐phase HPLC using β‐ or ‐β‐cyclodextrin as chiral mobile phase additive. A quantitative approach to experimental design has been developed. © 1993 Wiley‐Liss, Inc.