Premium
Chiral recognition by 1 H‐NMR, EPR, and ENDOR spectroscopy
Author(s) -
Stegmann Hartmut B.,
Mäurer Manfred,
Höfler Ulrike,
Scheffler Klaus,
Hewgill Frank
Publication year - 1993
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530050418
Subject(s) - chemistry , diastereomer , diamagnetism , paramagnetism , coupling constant , absolute configuration , electron paramagnetic resonance , chemical shift , nuclear magnetic resonance spectroscopy , spectroscopy , computational chemistry , nuclear magnetic resonance , stereochemistry , magnetic field , physics , particle physics , quantum mechanics
Chiral recognition with magnetic methods requires the formation of diastereomers. Due to the variety of appropriate reactions, hydrogen bond formation, esterification, and acetalization as well as host–guest interactions were chosen for basic investigations. The results obtained indicate that in the case of diamagnetic compounds the chemical shifts and for paramagnetic compounds the β‐proton coupling constants are the most useful parameters. By combination of both pieces of information, assignment of the absolute configuration was achieved. © 1993 Wiley‐Liss, Inc.