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Preparative scale enantioseparation of a chiral epoxide: Comparison of liquid chromatography and simulated moving bed adsorption technology
Author(s) -
Nicoud RogerMarc,
Fuchs Géraldine,
Adam Philippe,
Bailly Michel,
Küsters Ernst,
Antia Firoz D.,
Reuille Robert,
Schmid Emil
Publication year - 1993
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530050415
Subject(s) - simulated moving bed , chemistry , cellulose triacetate , epoxide , chromatography , adsorption , cellulose , organic chemistry , catalysis
The feasibility of using simulated moving bed technology (SMB) for chiral separation on cellulose triacetate is demonstrated on the preparative scale: 1 kg of a chiral epoxide has been separated. On comparing SMB technology with conventional liquid chromatography it turns out that the main advantage of SMB lies in the significant reduction of mobile phase consumption. The process design for SMB is made theoretically and the predictions are confirmed by our pilot study. © 1993 Wiley‐Liss, Inc.