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Enzymatic and chromatographic chiral discrimination of racemic (thio)glycidyl esters: Part II. Optical resolution of racemic (thio)glycidyl esters on modified cellulose chiral stationary phases
Author(s) -
Wagner Jürgen,
Offhauss Ulrike,
Martin Arnim A.
Publication year - 1993
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530050413
Subject(s) - chemistry , thio , propionate , cellulose , resolution (logic) , chromatography , column chromatography , organic chemistry , enantiomer , artificial intelligence , computer science
Chiral chromatography on cellulose tris(3,5‐dimethylphenyl carbamate) (Chiralcel OD) and cellulose tribenzoate (Chiralcel OB) coated stationary phases has been successfully used for the optical resolution of rac ‐(thio)glycidyl esters (acetate, propionate, butyrate). Glycidyl esters could sufficiently be resolved on the OD column whereas for the thio analogues baseline resolution is obtained on CSP OB using hexane/2‐propanol mobile phases. The separation factor (α) and resolution ( R S ) depend on column temperature, eluent composition, and flow rate, respectively. Best results were obtained for the butyrates and at low temperatures in general. © 1993 Wiley‐Liss, Inc.