Preparative separation of amino acid enantiomers as  N ‐TFA,  O ‐isopropyl derivatives by continuous countercurrent gas‐liquid chromatography | Zendy

Sato Katsuya | Zendy; Watabe Katsunori | Zendy; Ihara Toshihide | Zendy; Hobo Toshiyuki | Zendy

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Preparative separation of amino acid enantiomers as N ‐TFA, O ‐isopropyl derivatives by continuous countercurrent gas‐liquid chromatography

Author(s) -

Sato Katsuya,

Watabe Katsunori,

Ihara Toshihide,

Hobo Toshiyuki

Publication year - 1993

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.530050411

Subject(s) - chemistry , enantiomer , countercurrent exchange , chromatography , diluent , isopropyl , countercurrent distribution , leucine , valine , amino acid , countercurrent chromatography , gas chromatography , organic chemistry , high performance liquid chromatography , biochemistry , physics , thermodynamics

Preparative separation of derivatives of amino acid enantiomers was carried out by a countercurrent gas–liquid chromatography (CCGLC) with chiral liquid phases, N ‐stearoyl‐ L ‐valine tert ‐butylamide and/or N ‐stearoyl‐ L ‐leucine tert ‐butylamide. In order to make effective use of these phases and also to lower the viscosity, Apiezon C was added as diluent. Through a repeated operation of a temperature gradient, purities more than 99% of leucine and α‐amino butyric acid derivatives were proved to be obtained. © 1993 Wiley‐Liss, Inc.

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