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High‐Performance liquid chromatography (HPLC) chiral separations of guaifenesin, methocarbamol, and racemorphan
Author(s) -
Demian Iulia
Publication year - 1993
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530050409
Subject(s) - chemistry , enantiomer , chromatography , high performance liquid chromatography , chiral stationary phase , chiral column chromatography , silica gel , phase (matter) , organic chemistry
HPLC chiral separations on silica gel coated with derivatized cellulose stationary phases are described. Most examples make use of the Chiralcel OD column from Daicel, Inc. With a judiciously chosen mobile phase, baseline separations of the enantiomers can be achieved. If those separations are used as a base for enantiomeric purity determination, detectable limits of 0.1% of the minor enantiomer are routinely accessible. Examples are given concerning separations of guaifenesin, methocarbamol, and racemorphan. © 1993 Wiley‐Liss, Inc.
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