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Benzoylcellulose derivatives as chiral stationary phases for open tubular column chromatography
Author(s) -
Francotte Eric,
Grolimund Karl,
Juvancz Zoltan
Publication year - 1993
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530050408
Subject(s) - chemistry , supercritical fluid chromatography , chiral column chromatography , chromatography , countercurrent chromatography , gas chromatography , chromatography column , cellulose , column chromatography , stationary phase , polymer , polyethylene glycol , hydrophilic interaction chromatography , resolution (logic) , chiral stationary phase , high performance liquid chromatography , organic chemistry , artificial intelligence , computer science
The application of cellulose‐based stationary phases for chiral separations has been extended to open tubular column chromatography. Efficient columns were obtained by coating the capillaries with mixtures of chiral cellulose materials and conventional achiral stationary phases for gas chromatography. In this study, various siloxane and polyethylene glycol polymers were used as achiral components and mixed with different substituted benzoylcellulose derivatives as chiral components. Systematic investigations were carried out to determine the optimal ratio for the components of the stationary phase. Depending on the chromatographic mode—gas chromatography (GC) or supercritical fluid chromatography (SFC)—the stationary phases were found to behave differently. The applicability of the technique was demonstrated by the resolution of various racemic compounds. © 1993 Wiley‐Liss, Inc.