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Use of chiral β‐lactones for the synthesis of chiral LC phases
Author(s) -
Lohmann Dieter,
Däppen Richard
Publication year - 1993
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530050312
Subject(s) - chemistry , chiral stationary phase , chiral column chromatography , resolution (logic) , lactone , high performance liquid chromatography , combinatorial chemistry , chromatography , chiral resolution , organic chemistry , stationary phase , chiral derivatizing agent , phase (matter) , chirality (physics) , enantiomer , chiral symmetry , physics , quantum mechanics , artificial intelligence , computer science , nambu–jona lasinio model , quark
Chiral β‐lactones offer an easy and economic approach to novel chiral R‐ or S‐configurated LC phases. The preferred method for their preparation is based on conventional ready‐to‐use aminopropyl‐functionalized silicas, e.g., aminopropyl HPLC columns. The new stationary phases can be used for analytical and preparative separations and are particularly suitable for the resolution of rotatory and heterocyclic stereoisomers. Applications in the LC, SFC, and TLC mode are possible, including the use of β‐lactone‐based mobile phase additives in a “push–pull” combination. A large variety of organic solvents can be used as eluents. © 1993 Wiley‐Liss, Inc.