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Direct high‐performance liquid chromatography (HPLC) separation of etodolac enantiomers using chiral stationary phases
Author(s) -
Caccamese Salvatore
Publication year - 1993
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530050311
Subject(s) - chemistry , etodolac , enantiomer , chromatography , derivatization , high performance liquid chromatography , chiral stationary phase , chiral column chromatography , organic chemistry , biochemistry
The enantiomers of the antiinflammatory drug Etodolac were separated without derivatization on Chiralcel OD and Pirkle (R)‐DNBPG columns. Enantiomeric purity can be determined in less than 10 min. Optimization of separation was evaluated using various concentrations of 2‐propanol (doped with TFA) in hexane as the mobile phase. © 1993 Wiley‐Liss, Inc.