Premium
Preparative resolution of some 5,5‐hydantoin derivatives via formation of diastereoisomeric salts
Author(s) -
Coquerel Gérard,
Petit MarieNoëlle,
Bouaziz Roger,
Depernet Dominique
Publication year - 1992
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530040612
Subject(s) - chemistry , hydantoin , resolution (logic) , alkalinity , diastereomer , base (topology) , crystallization , organic chemistry , combinatorial chemistry , mathematical analysis , mathematics , artificial intelligence , computer science
Several preparative resolutions of 5,5‐disubstituted hydantoins have been achieved via fractional crystallization of diastereoisomeric salts. The process can be extended by making use of the difference between the variation of solubilities of the hydantoins and their salts with α‐methylbenzylamine as a function of the alkalinity of the medium. Optimization for each resolution procedure involves a refinement of the excess amount of base needed. © 1992 Wiley‐Liss, Inc.