Premium
Resolution of terfenadine enantiomers by β‐cyclodextrin chiral stationary phase high‐performance liquid chromatography
Author(s) -
Weems Henri,
Zamani Kaveh
Publication year - 1992
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530040411
Subject(s) - chemistry , enantiomer , terfenadine , cyclodextrin , chromatography , chiral stationary phase , chiral column chromatography , resolution (logic) , chiral derivatizing agent , stationary phase , high performance liquid chromatography , phase (matter) , organic chemistry , pharmacology , artificial intelligence , computer science , medicine
Enantiomers of terfenadine were resolved by high‐performance liquid chromatography (HPLC) using a chiral stationary phase (CSP) column packed with β‐cyclodextrin (β‐CD) covalently bound to silica. Separation was achieved in both the reverse phase and normal phase modes. Resolution of enantiomers was confirmed by ultraviolet‐visible absorption, circular dichroism, and mass spectral analysis.