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Polypeptide models of elastin: CD and NMR studies on synthetic poly(X‐Gly‐Gly)
Author(s) -
Tamburro A. M.,
Guantieri V.,
Scopa A.,
Drabble J. M.
Publication year - 1991
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530030417
Subject(s) - chemistry , elastin , stereochemistry , pathology , medicine
Poly(X‐Gly‐Gly), simple structural models for the hydrophobic, proline‐devoid, regions of elastin, have been synthesized and studied by circular dichroism and NMR spectroscopies. The results gave evidence of type II β‐turns as the only ordered structure present in the polymers. The stability of the turns has been shown to decrease on hydration and to increase in the series Leu < Ala < Val < Ile.