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An alternative to Urry's model for the gramicidin transmembrane channels
Author(s) -
Lorenzi Gian Paolo
Publication year - 1991
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530030416
Subject(s) - chemistry , dimer , head (geology) , transmembrane protein , gramicidin , stereochemistry , transmembrane domain , membrane , receptor , biochemistry , organic chemistry , geomorphology , geology
It is suggested that the conducting transmembrane channels formed by the linear gramicidins A, B and C may be head‐to‐head (formyl end‐to‐formyl end) dimers of double‐stranded parallel β‐helices. This possibility is not in conflict with any of the various experimental findings bearing on the molecular organization of the channels and represents a plausible alternative to Urry's model of a head‐to‐head dimer of single‐stranded β 6.3 ‐helices.