Premium
A chiral stationary phase which affords unusually high levels of enantioselectivity
Author(s) -
Pirkle William H.,
Deming Kris C.,
Burke John A.
Publication year - 1991
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530030308
Subject(s) - chemistry , chiral stationary phase , enantiomer , analyte , chiral derivatizing agent , stationary phase , phase (matter) , chiral column chromatography , enantioselective synthesis , chromatography , combinatorial chemistry , organic chemistry , catalysis
A chiral stationary phase (CSP) derived from N ‐(1‐naphthyl) leucine has been prepared. This CSP is conceptually similar to the CSP derived from N ‐(2‐naphthyl)alanine and was expected to separate the enantiomers of the same clientele of analytes as does the latter. The magnitudes of the separation factors observed on the two CSPs may differ markedly for a given analyte, the new CSP often affording much greater enantioselectivity.