Premium
Optical resolution of two isomeric naphthylalanines by immobilized enyzmes
Author(s) -
Pugnière Martine,
Castro Bertrand,
Previero Aldo
Publication year - 1991
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530030305
Subject(s) - chemistry , hydrolysis , resolution (logic) , alanine , immobilized enzyme , enzyme , enzymatic hydrolysis , chromatography , enzyme catalysis , organic chemistry , amino acid , combinatorial chemistry , stereochemistry , biochemistry , artificial intelligence , computer science
Optical resolution of β‐(1‐naphthyl)alanine and β‐(2‐naphthyl)alanine have been efficiently carried out through enzymatic hydrolysis of their methyl ester and/or N ‐acetyl ester derivatives by immobilized enzymes. Difficulties related to the lipophilic character of these amino acids were overcome by using emulsions of n ‐butyl acetate–water as reaction medium. The use of an automatic recirculating apparatus allowed reproducible and repetitive use of the immobilized biocatalysts.