Direct measurement of enantiomeric ratios of enzymatic resolution by chiral high‐performance liquid chromatography | Zendy

Wu ShihHsiung | Zendy; Lai SuYuan | Zendy; Lin ShuLing | Zendy; Chu FeiYa | Zendy; Wang KungTsung | Zendy

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Direct measurement of enantiomeric ratios of enzymatic resolution by chiral high‐performance liquid chromatography

Author(s) -

Wu ShihHsiung,

Lai SuYuan,

Lin ShuLing,

Chu FeiYa,

Wang KungTsung

Publication year - 1991

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.530030111

Subject(s) - chemistry , enantiomer , propionate , enantiomeric excess , chromatography , resolution (logic) , substrate (aquarium) , chiral derivatizing agent , organic chemistry , chiral column chromatography , enantioselective synthesis , catalysis , oceanography , artificial intelligence , geology , computer science

(R)‐ and (S)‐Methyl 2‐(phenoxy)propionate and their acids could be separated simultaneously by a Chiralcel OD or OK column, while (R)‐ and (S)‐methyl 2‐(4‐chlorophenoxy)propionate and their acids were separated concurrently only by an OK column. This is a novel and facile way to measure the enantiomeric excesses of the remaining substrate and product in the reaction of enzymatic resolution; enantiomeric ratios could then be calculated.

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