An HPLC procedure for the enantiomeric purity of an optically active cytosine analogue using ligand exchange | Zendy

Pack Edward J. | Zendy; Bleiberg Bonnie | Zendy; Rosenberg Ira E. | Zendy

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An HPLC procedure for the enantiomeric purity of an optically active cytosine analogue using ligand exchange

Author(s) -

Pack Edward J.,

Bleiberg Bonnie,

Rosenberg Ira E.

Publication year - 1990

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.530020414

Subject(s) - chemistry , enantiomer , cytosine , ligand (biochemistry) , high performance liquid chromatography , phenylalanine , optically active , chiral column chromatography , chromatography , stereochemistry , combinatorial chemistry , organic chemistry , dna , amino acid , biochemistry , receptor

An acylonucleotide analogue, 1‐[3‐hydroxy‐2‐(phosphonyl‐methoxy)propyl]cytosine (HPMPC), has shown activity against herpes simplex Type I and Type II viruses. An HPLC separation of the R‐ and S‐enantiomers of HPMPC by ligand exchange using a mobile phase containing phenylalanine as the chiral modifier and copper(II) as the metal ion is reported.

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