Premium
Enantiomeric resolution of DNS‐amino acids by ligand exchange chromatography: Comparison of different chiral amino acid amides as additives to the mobile phase
Author(s) -
Girelli A. M.,
Sinibaldi M.
Publication year - 1990
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530020311
Subject(s) - chemistry , enantiomer , amino acid , chelation , ligand (biochemistry) , phase (matter) , resolution (logic) , chiral derivatizing agent , chromatography , metal , chirality (physics) , enantiomeric excess , organic chemistry , chiral column chromatography , enantioselective synthesis , catalysis , receptor , biochemistry , chiral symmetry breaking , physics , quantum mechanics , artificial intelligence , computer science , nambu–jona lasinio model , quark
A study developing enantiomeric separations by metal chelate additives to the mobile phase in reversed‐phase liquid chromatography is reported. In particular the use of Cu(II) complexes of L‐prolinamide (L‐ProNH 2 ) and L‐valinamide (L‐ValNH 2 ) is examined and discussed. Interestingly, for a series of DNS‐amino acids these selectors show higher enantioselectivity than that obtained with the corresponding nonderivatized amino acid–Cu(II) complexes.