Eudismic analysis of a series of muscarinic ligands carrying a 1,3‐oxathiolane nucleus | Zendy

Gualtieri F. | Zendy; Romanelli M. N. | Zendy; Teodori E. | Zendy

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Eudismic analysis of a series of muscarinic ligands carrying a 1,3‐oxathiolane nucleus

Author(s) -

Gualtieri F.,

Romanelli M. N.,

Teodori E.

Publication year - 1990

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.530020204

Subject(s) - chemistry , muscarinic acetylcholine receptor , nucleus , agonist , enantiomer , antagonist , complement (music) , stereochemistry , etiolation , receptor , neuroscience , biochemistry , psychology , complementation , gene , phenotype , enzyme

Eudismic analysis was performed on a set of 14 muscarinic ligands carrying a 1,3‐oxathiolane nucleus, in order to obtain information about both the existence of receptor subgroups and of agonist and competitive antagonist interaction sites. The results obtained were compared with those from a study of the enantioselectivity of the pairs of enantiomers. The two approaches do not appear to be completely equivalent and would seem to complement each other usefully.

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