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Eudismic analysis of a series of muscarinic ligands carrying a 1,3‐oxathiolane nucleus
Author(s) -
Gualtieri F.,
Romanelli M. N.,
Teodori E.
Publication year - 1990
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530020204
Subject(s) - chemistry , muscarinic acetylcholine receptor , nucleus , agonist , enantiomer , antagonist , complement (music) , stereochemistry , etiolation , receptor , neuroscience , biochemistry , psychology , complementation , gene , phenotype , enzyme
Eudismic analysis was performed on a set of 14 muscarinic ligands carrying a 1,3‐oxathiolane nucleus, in order to obtain information about both the existence of receptor subgroups and of agonist and competitive antagonist interaction sites. The results obtained were compared with those from a study of the enantioselectivity of the pairs of enantiomers. The two approaches do not appear to be completely equivalent and would seem to complement each other usefully.